Convert Pharmaceuticals is a preclinical-stage research and development company, building a proprietary drug pipeline that exploits the presence of hypoxia in tumors.
Hypoxia constitutes a therapeutic obstacle as it contributes to the development of resistance to conventional anti-cancer treatments. Convert Pharmaceuticals is combining knowledge of the tumor microenvironment with expertise in drug and biomarker development to develop efficacious and well-tolerated Hypoxia-Activated Prodrugs (HAPs) that target a well-defined patient population.
Convert Pharmaceuticals builds on the expertise in tumor hypoxia and cancer treatment of one of its founders, Prof. Philippe Lambin, together with that of the pioneering scientists, Assoc. Prof. Adam Patterson and Dr. Jeff Smaill of the Auckland Cancer Society Research Centre, located at the University of Auckland, New Zealand.
Used in combination with appropriate biomarkers and imaging tools to identify the patient population most likely to benefit, the concept of Hypoxia-Activated Prodrugs (HAPs) has the potential to improve patient outcomes especially by complementing existing therapies (chemo-, radio-, hormone-, immunotherapy or targeted agents).
Arne has been involved in Convert Pharmaceuticals since its incorporation and heads non-clinical development including CMC, PK/PD, toxicology and the biomarker program. Previously, as an R&D Director, Arne managed the drug development programs of several oncology-focused companies, including pre-clinical stage companies PX Biosolutions (cancer vaccines) and Metaptys (cancer metabolism), and clinical-stage companies such as Normoxys (tumor hypoxia alleviation). Arne is author of more than 60 publications in international scientific peer-reviewed journals and inventor of 3 patents. He holds a MSc and PhD in Biochemistry from the University of Ghent (Belgium) where he worked as a post-doctoral researcher on various aspects of preclinical and clinical development with a focus on natural products.
Dominique joined Convert Pharmaceuticals in April 2017, and brings more than 20 years global clinical development and regulatory affairs experience with both small molecules and biologicals. Her previous role was Chief Medical Officer with Ablynx, where she was responsible for clinical development and regulatory affairs of clinical programs in hematology, immunology and virology. Prior to this, she was Director Regulatory Sciences-Europe for oncology and virology products with Bristol-Myers Squibb. Dominique started her career with Janssen Research Foundation (J&J) in oncology clinical development. She obtained her Medical degree from the University of Antwerp (Belgium).
Prof. Philippe Lambin is a clinician, radiation oncologist and pioneer in translational research with a focus on tumor hypoxia and decision support systems, including hypoxia imaging and Radiomics, a concept he co-invented. Philippe is Professor at the University of Maastricht, co-author of more than 402 peer-reviewed scientific papers, and co-inventor of more than 18 patents. Moreover, Philippe has extensive experience with clinical trials. He has received an ERC advanced grant laureate in 2016 and is currently involved in several successful European grants including the Marie Curie Training network PREDICT, which he is the initiator of, and two NIH grant from the US. Philippe obtained his MD from UCL (Louvain-la-Neuve, Belgium) and Ph.D. in Radiation Biology from the Université Paris-Sud (France).